Trials

We suggest investigating whether inhalation of the antibiotic levofloxacin is an alternative to systemic treatment for CAP in terms of treatment response, and at the same time reducing antimicrobial resistance and preserving the gut microbiome. We hypothesize that this reduces selection of resistant strains in the gut and reduces side-effects while preserving efficacy for treating […]

OxyCOP is a clinical multicenter cluster randomized trial investigating controlled oxygen therapy in patients admitted with acute exacerbation of chronic obstructive pulmonary disease. We aim to determine whether using a strategy with a moderate oxygen target (SpO2 93-96%), compared to a low oxygen target SpO2 88-92%, leads to shorter admission and lower mortality. Expected start […]