Trials

There is a need to clarify whether systemic antibiotic treatment against Pseudomonas aeruginosa in patients with chronic pulmonary diseases is beneficial. We therefore conducted a randomized, good clinical practice (GCP) monitored, controlled trial to determine whether dual systemic antibiotics against Pseudomonas aeruginosa in patients with COPD non-CF bronchiectasis, or asthma, and no current indication for […]

Treatment with systemic corticosteroids in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) is associated with debilitating adverse effects. Therefore, strategies to reduce systemic corticosteroid exposure are urgently required and might be offered by a personalised biomarker-guided approach to treatment. The aim of this study was to determine whether an algorithm based on […]

We conducted a randomized, placebo-controlled, double-blinded trial to investigate the effect of prednisolone on the functional coagulation in healthy individuals, as well as the effect of prednisolone on selected hemostatic parameter The article is available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377059/ Statistical Analysis Plan – SAP (Download)

The Procalcitonin And Survival Study (PASS) – A Randomised multi-center investigator-initiated trial to investigate whether daily measurements biomarker Procalcitonin and pro-active diagnostic and therapeutic responses to abnormal Procalcitonin levels, can improve survival in intensive care unit patients. To investigate whether a treatment strategy, that is guided by daily measurements of the infection biomarker “Procalcitonin” can […]

The primary aim of this study was, among patients with acute ventilator-dependent respiratory failure and complete follow-up, to determine whether initial profound alveolar damage (high SPD) or damage to conductive airways (high CC16) was associated with ARDS and has a detectable clinical impact one month after intensive care admittance, i.e., failure to successfully wean the […]